Traditional uses, phytochemical and pharmacological profiles, and toxicity of <i>Enantia chlorantha</i> (Oliver) : An overview

doi:10.5348/M05-2016-4-RA-2

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Traditional uses, phytochemical and pharmacological profiles, and toxicity of Enantia chlorantha (Oliver) : An overview

Olivier Tene Tcheghebe¹, Francis Ngouafong Tatong², Armel Jackson Seukep³

¹PhD, Inorganic Chemistry Department, Faculty of Science, P.O. Box 812, University of Yaounde I.
²Master degree, Chemistry Department, University of Dschang, P.O Box 67 Dschang; West Region, Cameroon.
³Master degree, Biochemistry Department, University of Dschang, P.O Box 67Dschang; West Region, Cameroon.

Article ID: 100004M05OT2016
doi:10.5348/M05-2016-4-RA-2

Address correspondence to:
Dr. Olivier Tene Tcheghebe
Dschang, Cameroon, phone code: (237)

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How to cite this article

Tene Tcheghebe O, Ngouafong Tatong F, Seukep AJ. Traditional uses, phytochemical and pharmacological profiles, and toxicity of Enantia chlorantha (Oliver) : An overview. Edorium J Med 2016;3:12–18.

Abstract


This article aims to provide a comprehensive review on the traditional uses, phytochemical and pharmacological profiles as well as the toxicity of Enantia chlorantha (Oliver) We have examined most of the publications on this plant and focused our attention on the active metabolites of its extracts which support its traditional uses. Enantia chlorantha is reported to be used in folkloric medicine for the treatment of many diseases, such as malaria, aches, wounds, boils, vomiting, yellow bitter, fever, chills, sore, spleen in children, hepatitis, worms, intestinal spasms, sexual asthenia, jaundice, urinary tract infections, typhoid fever, leprosy spots, tuberculosis, gastric and duodenal ulcers. It can also serve as a haemostatic agent, and as an uterine stimulant. Enantia chlorantha stem bark has been scientifically studied for its several pharmacological activities. These include: antimalarial, antimicrobial and antibacterial, antioxidant, anti-Helicobacter pylori, anticonvusion and anti-inflammatory, analgesic and antipyretic, antiviral, gastro protective and enhancing male fertility. Some bioactive constituents such as saponins, flavonoids, alkaloids, phenols, reducing sugar and cardiac glycoside significantly present in the plant extracts, support its multiple properties and uses in traditional medicine. Moreover, it is demonstrated that this plant extract can be safely taken until a dose of 500 mg/kg body weight. We sincerely hope that we have provided a data base for proper evaluation of Enantia chlorantha extracts which could lead to the discovery of new and more effective drugs.
Keywords: Enantia chlorantha, Pharmacology, Toxicity

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Author Contributions
Olivier Tene Tcheghebe – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Francis Ngouafong Tatong – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Armel Jackson Seukep – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published

Guarantor of submission
The corresponding author is the guarantor of submission.

Source of support
None

Conflict of interest
Authors declare no conflict of interest.

Copyright
© 2016 Olivier Tene Tcheghebe et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.

About The Authors

Olivier Tene Tcheghebe (PhD) Faculty of science, University of Yaounde I, Yaounde, Cameroon. He earned undergraduate degree and postgraduate degree from University of Yaounde I, Yaounde, Cameroon). He has published five research papers in national and international academic journals. His research interests include coordination polymers based on tris(oxalato)metalate(III) anion, medicinal plants activities against tropical diseases such as malaria, typhoid fever, lymphatic filariasis gastric and duodenal ulcers, and the treatment of cancers with natural products.

Francis Tatong Ngouafong (PhD Student) Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon. He earned undergraduate degree from Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon. He has published four research papers in national and international academic journals. His research interest includes natural products.

Armel Jackson Seukep (PhD Student) Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon. He earned undergraduate degree from Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon and postgraduate degree from Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon. He has published 19 research papers in national and international academic journals and authored one book. His research interests include antibacterial activities, anticancer activities, multidrug resistant phenotypes (all these from natural products).